Surname Isaac Efrain (Isaac Efrain 
) , throughout the world, is an extremely rare family name. The surname Isaac Efrain is habitual in Latin America and the Caribbean, particularly Chile, where it is a very rare surname. More frequently, Isaac Efrain is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Isaac Efrain | Peru, Chile, Mexico, Ecuador, Costa Rica |